White Blood Cell or (WBC) which is also called “Leukocyte” is one of the cellular components of blood that does not have hemoglobin, unlike red blood cells. The white blood cell is a nucleated cell and has the ability to move.
White blood cells (WBCs) are part of the body’s immune system.
They help fight infection and defend the body against other external substances.
Indeed these cells protect the body against pathogenic and external agents and cancer cells, and dead and damaged cells are removed from the body by these cells.
Blood is made up of red blood cells, white blood cells, plasma, and platelets. Although white blood cells are only about 1% of the total blood cells in humans, their impact is significant.
White blood cells have different types and different functions depending on their type. Some are involved in identifying intruders. Some kill harmful bacteria. Others make antibodies to protect your body from exposure to bacteria and viruses.
They are also known by other names, which include:
Leukocyte Differential Count
Peripheral Differential
WBC Count Differential
Diff
Blood Differential
Differential Blood Count
CBC with Diff
White blood cells due to constant fighting against external agents are considered the cells of the immune system.
In this way that they are moved throughout the body through the bloodstream to fight viruses, bacteria, and other external invaders.
When the body gets an infection and a certain area is attacked, they are released from the blood vessels to fight and destroy the infection to prevent the body from getting sick.
The mentioned cells are made in the bone marrow and stored in the blood and lymph tissues of the body.
Since some of them have a short life of 1-3 days, the bone marrow is constantly producing white blood cells.
White blood cells begin in the bone marrow in a process called hematopoiesis. All blood cells originate from a common hematopoietic stem cell (HSC). This stem cell is also called “potent”. These stem cells differentiate or specialize in different stages.
HSC cells first differentiate into lymphoid or myeloid stem cells.
Lymphoid stem cell gives rise to the lymphoid cell line. This family of cells produces B cells and T cells
Myeloid stem cells give rise to cells called myeloblasts. These further transform into macrophages, monocytes, neutrophils, basophils, and eosinophils. Myeloblasts can also develop into red blood cells and blood platelets.
Bone marrow produces five main types of white blood cells (WBC) neutrophils, lymphocytes, monocytes, eosinophils, and basophils.
Natural killer cells directly attack abnormal cells, such as cancer or virus-infected cells, and destroy them.
Infections usually cause an increase in the white blood cell count, but there are other possible causes. The white blood cell count can be increased by overproduction. In other words, the body may release white blood cells early from the bone marrow.
Stress in any form can lead to the release of white blood cells. Some of the reasons for increasing the number of white blood cells are:
There are special conditions that may lead to a decrease in the number of white blood cells including:
In the description of the types of white blood cells, it was investigated that neutrophils are the first responders to our immune system.
A decrease in neutrophils during chemotherapy, known as chemotherapy-induced neutropenia, which increases the risk of serious infection.
Neutropenia makes it harder for the body to fight infections. As a result, bacteria that are usually not very harmful can cause serious blood diseases.
There is no symptom of A low white blood cell count by itself. But due to the lack of white blood cells to fight the invader low numbers often lead to infection because there aren’t enough. However, some symptoms of infection may include the following:
. When you have a complete blood count (CBC) as part of a routine health checkup.
. When the results of a CBC fall outside the reference range
Manual microscopic examination of cells
How it is done?
White blood cell count (WBC) can be done manually with specially designed slides (Nebauer) or automatic counters. The latter is widely used and offers the advantage of higher accuracy and speed over manual techniques.
For differential counting and determining the percentage of white blood cells, a drop of blood is spread thinly on a glass slide, dried in air, and stained with Romanofsky dye, which is usually the Wright-Giemsa method. Then 200 cells are counted and classified. Machines have been developed to perform automatic differential counts, but they still need to be improved to manual techniques regarding reliability and the ability to detect morphological abnormalities.
White blood cells (WBC), called leukocytes, circulate in the blood and lymphatic system and help protect the body against infections. They are an essential part of the immune system and play a role in inflammation, allergies, and protection against cancer.
The white blood cell (WBC) count has two components. The first component is the total white blood cell (WBC) count (leukocytes in one cubic millimeter of peripheral venous blood). The other component is the differential white blood cell (WBC) count, which measures the percentage of each type of leukocyte present in the same sample.
An increase in one type of leukocyte means a decrease in another percentage. Neutrophils and lymphocytes make up 75-90% of the total leukocytes. This type of leukocyte can be easily identified by its morphology in the peripheral blood smear or with automatic counters. The total number of leukocytes It has a wide range of average values, but many diseases may cause abnormal values
A differential count may accompany or follow a complete blood count (CBC) (a test often used as a general health check or may be done in the follow-up of abnormal results on a CBC. A differential count is often performed on an automated blood analyzer. It is sometimes done manually by a trained laboratory technician who examines the blood smear under a microscope.
An increase in the total WBC count (leukocytosis < WBC count 10,000) usually indicates infection, inflammation, tissue necrosis, or leukemic neoplasia. Trauma or emotional or physical stress may increase the WBC count. In some infections, especially sepsis, the WBC count may be very high and reach levels associated with leukemia, a leukemoid reaction that resolves quickly with successful infection treatment.
A decrease in the total WBC count (leaking, 4000 WBC count) occurs in many forms of bone marrow failure, for example, following antineoplastic chemotherapy or radiation therapy, brain injection diseases, severe infections, nutritional disorders, and autoimmune diseases).
The primary function of white blood cells (WBC) is to prevent infection and react against external bodies or tissues.
A differential white blood cell (WBC) count identifies and classifies the number of each type of white blood cell (WBC) in your blood sample.
There are five main types of white blood cells, each of which has different functions. A differential count shows that:
This information helps diagnose specific diseases affecting the immune system and bone marrow.
All white blood cells (WBC) are created from the same pluripotent stem cells in the bone marrow. However, beyond this origin, each cell line differentiates separately. Then most of the mature WBCs are released into circulation.
White blood cells are divided into granulocytes and non-granulocytes. Granulocytes include neutrophils, basophils, and eosinophils. Due to their multilobed nuclei, neutrophils are sometimes known as polymorphonuclear leukocytes (PMS). The normal range for absolute counts depends on age, sex, and ethnicity.
In the end, as a reminder, we must repeat that white blood cells are an army inside the body, protecting it from all possible dangers. Therefore, by knowing how they are formed and their exact number, as well as the symptoms of white blood cell deficiency, we can properly protect our health.
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Dr. Majid Zohrabi started treating his patients in Dubai in 2022 and continues his activities in private medical centers in the UAE.