What Level Of Creatinine Is Alarming?

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Creatinine test tells you how much Creatinine is in your blood and how well your kidneys are working.This substance, like urea, is part of the body’s waste and must be removed

The kidneys are responsible for excreting this substance. If you suffer from diseases such as diabetes or high blood pressure, the specialist will probably recommend creatinine to you during periodic checkups. These diseases can affect kidney function.

In this article from Drhealthandbeauty by Dr. Sanaz, we will explain to you the first step in preventing this problem, what is the level of creatinine in your blood under different conditions, and in the next step and in another article, we have discussed this question in detail: What Causes Creatinine Levels to Go Up and Down?

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What is the meaning of Creatinine in blood tests?

What is Creatinine or blood creatine? It is a substance in the body that is produced as a result of muscle metabolism and excreted from the kidneys. This substance is actually a type of protein that results from the metabolic processes of muscle cells. And if the level of blood creatinine is low or high, it will be an alarm for the patient.

Creatine is an excretory substance that, after entering the blood, is excreted from the body with the help of the kidneys. Checking the blood’s creatinine level can indicate the accurate or inaccurate functioning of the kidneys because the kidneys are the only organ responsible for eliminating Creatinine from the blood, and if they do not do this correctly, it is an alarm that the kidneys are not functioning properly.


Why is a creatinine test prescribed?

This test is an important indicator to check kidney function. High levels of Creatinine in the blood may be a warning sign that the kidneys are not working correctly. that the kidneys are not working properly. One of the most common disorders related to the kidneys that cause them not to work properly is kidney stones. The important thing is that by knowing What Are The First Signs Of Kidney Stone?   You can detect kidney stones in the early stages of their formation and treat them easily.

Creatinine blood tests help doctors diagnose kidney disease because a weak kidney can’t clear Creatinine as it usually would, leading to an increase in the level of Creatinine in the blood.

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How is the Creatinine test interpreted?

When the patient’s kidney function is to be examined, the creatine test is one of the routine tests that are performed for this purpose. An increase in Creatinine in the blood is usually a warning sign for reduced glomerular filtration and impaired kidney function.

Due to the constant level of Creatinine, its increase is a warning of chronic kidney damage, and unlike urea, it is not affected by liver problems.

In other words, the determination of blood creatinine and renal clearance of Creatinine are evaluated as indicators of kidney function. Serum or blood creatinine levels do not increase until kidney function is significantly impaired. This increase can be caused by a particular disease in the body.

It is not harmful to point out that the amount of Creatinine increases significantly when almost half of the nephrons are damaged in kidney disease, so it is not a sensitive indicator to check the onset of kidney disease, and other indicators must be checked and evaluated.

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Creatinine test conditions

To measure Creatinine, there are two sampling methods; One is to measure the amount of Creatinine with a blood sample and the other with a urine sample.

You don’t need to fast or have any special preparation to perform the Creatinine test. Of course, it is essential to inform your doctor about the medications you are taking because some drugs raise blood creatinine levels without causing damage to the kidney and can interfere with the results of the test.

Related: “What Drugs Should Be Avoided In Heart Failure?

Therefore, if you are using drugs such as cimetidine, non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen, chemotherapy drugs, and cephalosporins, be sure to inform your doctor because you may need to stop taking the drug before the test or Reduce the dosage.


When should blood creatinine be tested?

People who have kidney failure or are undergoing treatment for kidney diseases can check their treatment process through a full checkup test or a blood creatinine test. Depending on the type of disease and the condition of the patient, the frequency and interval of the test should be done as follows:

  • People with type 1 or type 2 diabetes should have their blood creatinine tested at least once a year.
  • Patients with kidney disorders should have urine and blood creatinine tests at regular intervals.
  • People who have diseases such as high blood pressure, diabetes or taking various drugs that affect the kidney should have urine and creatinine tests according to the doctor’s opinion.

Urine and blood creatinine tests do not require special preparation or conditions, and they do not require fasting. Of course, sometimes the doctor asks the patient to avoid eating meat for 24 hours before the test. Because meat consumption increases the percentage of Creatinine.

Note: To perform the test, the doctor takes urine, blood, and hemodialysis samples from the patient. If the doctor has scheduled a 24-hour appointment for the urine test, the patient must provide the sample to the doctor after 24 hours.

What is the average amount of Creatinine in the blood?

The average level of blood creatinine according to age and gender is according to the following table:

AgeNormal level of blood creatinine
AdultsWomen0.5 to 1.1 mg/dL
AdultsMen0.6 to 1.3 mg/dL
ChildrenYouth5 to 1.0 mg/dL
Childrenchildren0.3 to 0.7 mg/dL
ChildrenKid0.2 to 0.4 mg/dL
ChildrenInfant0.3 to 1.1 mg/dL
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What level of Creatinine is alarming?

Blood creatinine levels should be between 0.9 and 1.3 mg/dL for men and 0.6 and 1.1 for women. If the creatinine level is high, it is a warning of kidney problems and the disease should be diagnosed. Low levels of creatine occur very rarely and indicate a loss of muscle mass or malnutrition. 


Average level of Creatinine in pregnancy

During pregnancy, blood flow to the kidneys growths. This increases the excretion of Creatinine through urine. For this reason, pregnant women usually have lower levels of Creatinine in their blood. On average, the blood creatinine level of a pregnant woman is 80% of that of a non-pregnant woman. Of course, Creatinine levels will change during the trimesters of pregnancy. The average amount of Creatinine in pregnancy is as follows:

TrimesterNormal level of blood creatinine
First trimester of pregnancy0.63 to 0.86 mg/dL
Second trimester of pregnancy0.59 to 0.81 mg/dL
Third trimester of pregnancy0.61 to 0.87 mg/dL
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Are there any risks during creatinine testing?

There is minimal risk in having a blood test. You may have some pain or slight bruising where the needle was inserted, while most symptoms go away quickly. There is no risk in doing a urine test.

Your doctor may order a creatinine clearance test, which compares the level of Creatinine in your blood to the level of Creatinine in your urine. A creatinine clearance test may provide more accurate information about kidney function than a blood or urine test alone.

The amount of blood that the kidneys can make without Creatinine per minute is known as creatinine clearance. The level of Creatinine clearance in a young person who is healthy is about 95 mL/min for women and 120 mL/min for men. This means that a person’s kidneys will clear 95 to 120 milliliters of blood per minute without Creatinine.

For both tests, you may need to avoid eating meat for a certain period of time before the test. If you are taking creatine supplements, you should probably stop taking them.

Frequently asked questions

What is the average level of Creatinine in a blood test?

The average value of Creatinine in female adults is between 0.5 and 1.1 mg/dL, and in men, between 0.6 and 1.3 mg/dL.

What level of Creatinine requires dialysis?

It can decrease as you get older. A normal GFR is 90 mL/min or higher. GFR below 60 ml/min is not a sign of proper kidney function. A GFR below 15 ml/min indicates the need for kidney failure treatment, such as dialysis or transplantation.

What factors increase blood creatinine?

Creatinine levels can also be temporarily elevated by strenuous exercise or the use of certain drugs like sulfamethoxazole, trimethoprim, or chemotherapy drugs. Additionally, being pregnant or eating a diet high in red meat may play a role. Your body must clean your blood to function optimally.

What level of Creatinine is a warning for kidney failure?

A creatinine level greater than 1.2 for women and more significant than 1.4 for men may be an early sign of proper kidney function. As the kidney disease progresses, the level of Creatinine in the blood increases. This test is a measure of the kidney’s ability to remove waste materials and excess fluids from the blood.

conditions that can cause your kidney disease


The creatine test is actually the same blood test that shows the amount of Creatinine in your blood. The amount of this waste substance in the blood should be balanced and its increase or decrease can be a warning of a disorder or disease.

If you have symptoms related to kidney problems, your blood creatine levels should be checked. There are various reasons for the increase or decrease of creatine levels. Its rise can be a warning of kidney problems, complications of diabetes, heart failure or dehydration. Its decrease is usually a sign of malnutrition or loss of muscle mass. 

It is important to note that high level of blood creatinine, although it can be one of the signs of heart failure, but it is not one of the important signs. In the article “10 Signs Of Heart Failure That You Should Not Ignore“, we have examined the most important signs of heart failure.

After determining the cause of the change in the level of blood creatine, the doctor starts the necessary treatments to gradually bring the level back to normal.

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Author and specialist

Dr. Majid Zahrabi,


  • Board Certified Neurosurgeon
  • DHA certificate holder
  • Plantation certificate holder, France
  • Certified holder of Discogol, France
  • A pioneer in the non-surgical treatment of disc herniation in the Middle East and CIS countries.
  • Under the training and coaching of Professor Jacques Theron (founder of Discogel Therapy) since 2008
  • More than 400 successful cervical and 1300 lumbar discogel injections
  • Trained and certified several neurosurgeons and spine surgeons in the Middle East and CIS countries for the treatment of Discogel
  • Strong belief in patient-centered care planning and participation
  • Neurosurgeon and spine surgeon at Imam Khomeini and Amir Mazandarani Hospital, Sari, Iran, with more than 430 surgeries annually, 2000-2011
  • Neurosurgeon and spine surgeon at Farmaniyeh, Nikan and Yas Sepid Hospital, Tehran, Iran, with more than 400 surgeries annually, 2011-2012
  • Neurosurgeon at Iranian Hospital, Dubai, 2022-2023
  • Since 2015, he has been working as a reference doctor for the treatment of intervertebral disc herniation with Discogel and has trained many doctors of spine-related specialties in various countries of the Middle East and CIS in person/practically and online.



  • Individual training sessions under the direct supervision of Professor Jacques Theron in Discogel treatment, 2008-2020
  • Training sessions under the supervision of Professor Thierry Boye on spinal implants, 2007
  • Participation and presentation in several national and international medical and neuro-spinal conferences
  • Board certificate by Iran Neurosurgery Board, 2001
  • Neurosurgery assistant training course, Isfahan University of Medical Sciences, Isfahan, Iran, 1996-2001 (In 2001, he graduated from Isfahan University of Medical Sciences with the first rank in the country.
  • His thesis the titled:The Application of human amniotic membrane in repair of dura matter in dogs.” ( It was happening for the first time in the world. )
  • General medical education, Tabriz University of Medical Sciences, Tabriz, Iran, 1984-1993


Published books:

  • CT scan of the brain for doctors
  • Etiology and treatment of painful spine disorders
  • Atlas of diagnosis, prevention, and treatment of spine disorders
  • The most common mistakes in the treatment of spinal disorders
  • Reading brain CT scan in simple language (3rd place in the book of the year)
  • Treatment of head and spine injuries

Publications and articles:

  • Bacteriostatic and bactericidal effects of DISCOGEL® (https://www.researchgate.net/)
  • Muscle recovery, reduction of pain, and improvement of movement strategies in patients with lumbar discopathy after injection of Discogel.
  • The article on the initial results of the treatment of intervertebral disc herniation with discogel injection, which won the second-best poster rank at the Pan Arab International Congress of Interventional Radiology (March 14-16, 2015) and was accepted for presentation at the Chicago Pain Congress.
  • The use of human amniotic membrane in dura mater repair in dogs, a study for the first time in the world.



  • Annual Congress of Physiotherapists of Iran, 2019
  • Chicago International Pain Congress, 2019
  • Iran International Pain Management Congress, 2018
  • Annual Congress of Physiotherapists of Iran, 2018
  • Presentation of Discogel as an innovative solution for the treatment of spinal disc herniation in Armenia for orthopedic specialists and neurosurgeons, 2017
  • First Live Workshop and Seminar on Minimally Invasive Disc Therapy (DISCON), 2017
  • Presentation of Discogel as an innovative solution for the treatment of spinal disc herniation in Azerbaijan for orthopedic specialists and neurosurgeons, 2016
  • Seminar of Iranian official managers, 2016
  • Presentation of Discogel as an innovative solution for the treatment of spinal disc herniation in Tajikistan for orthopedic specialists and neurosurgeons, 2016
  • International Neurological Intervention Congress in Iran, 2014
  • Educational seminar for nurses on treatment approaches for head and spine trauma, 2014
  • Educational seminar for general practitioners on treatment approaches for head and spine trauma, 2014
  • Speech at the Retraining Seminar for General Practitioners and Specialists in Dubai (Discon) in 2017
  • Speech in the internal retraining courses of Irani Hospital, Dubai
  • Holding lecture sessions and practical workshops on the treatment of intervertebral disc herniation with discogel injection in Azerbaijan, Tajikistan, Ukraine, Oman, and Armenia during the years 2015 to 2021.
  • Giving a lecture and holding a practical workshop for neurosurgeons in Vietnam at Ho Chi Minh City University in 2023

Dr. Majid Zohrabi started treating his patients in Dubai in 2022 and continues his activities in private medical centers in the UAE.